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Topical GHK-Cu is regulated as a cosmetic ingredient

3.2 Machine learning modeling For this stage, we took the molecules obtained from the output of each of the 9 ensemble dockings to generate 9 ML models capable of classifying molecules as inactive or active with respect to each identified family of inhibitors

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The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons